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- 8:00 - 18:00
- 8:00 - 18:00
- 8:00 - 18:00
- 8:00 - 18:00
- 8:00 - 18:00
- 8:00 - 18:00
- 8:00 - 18:00
Prenatal Fluorescence in situ Hybridization (FISH) Tests
FISH testing is a molecular cytogenetic analysis that identifies specific chromosomal abnormalities by evaluating presence or absence of fluorescent signals in metaphase chromosomes or interphase nuclei. FISH results for rapid diagnosis of aneuploidy are typically provided within 48 hours from the receipt of the specimen.
Clinical Indications For FISH Test
Advanced maternal age
Abnormal ultrasound
Abnormal maternal serum screen
Fetal demise
Family history of microdeletion/microduplication syndrome
Family history of chromosomal abnormality
Samples For Prenatal Chromosome Analysis
Amniotic Fluid
Chorionic Villi
Types Of Prenatal FISH Studies
FISH For Aneuploidy and Polyploidy
FISH For Microdeletion/Microduplication Syndromes
FISH For Subtelomeric Rearrangements
FISH For aCGH Confirmation
Advantages and Limitations
FISH testing can rapidly detect and characterize submicroscopic chromosome abnormalities.
FISH testing has the ability to analyze the abnormalities on metaphase chromosomes from cultured samples as well as interphase cells from specimens that cannot be cultured.
FISH testing has high sensitivity and specificity.
The main limitation of FISH analysis is that it only provides information about the specific locus or gene tested.
